Dupuytren's nodule differential diagnosis

Dupuytren's disease is the shortening and thickening of ligaments that anchor skin to the palmar fascia. The disease initially presents as a firm nodule (or multiple nodules) on the palm of the.. Because of the rare entity of Dupuytren's disease in childhood, diagnosis of nodules and fibrotic bands in children's hands must be assigned with great caution. Exact anamnesis, location of the lesion, and suspicious diagnosis must be mentioned to the pathologist in the case of biopsy or excision Dupuytren's disease is a progressive condition that causes the fibrous tissue of the palmar fascia to shorten and thicken. The disease is common in men older than 40 years; in persons of Northern European descent; and in persons who smoke, use alcohol, or have diabetes. Patients present with a small Dupuytren's contracture, also called Viking disease, or palmar fibromatosis, is a fibrosing condition that characteristically presents as a firm nodularity on the palmar surface of the hand with coalescing cords of soft tissue on the webs and digits

Dupuytren nodules form early in the course of the disease and usually precede the development of joint contracture. These nodules can present with or without pain and can be multiple in numbers (Fig. 1). Currently, although nodules may be symptomatic with pain, no specific intervention is recommended Hand and wrist MRI scan: Dupuytren's tissue give a low intensity signal (not many white dots) on T1 and T2, but if the nodule or the fascia is cellular it is more intense (more white), and this can tell the surgeon how much tissue needs to be removed to reduce the chance of recurrence

Dupuytren's Disease: Diagnosis and Treatment - American

with the diagnosis. If a patient is unable to lay his or her palm flat on a tabletop, the test Steroid injections into grade 1 Dupuytren's disease nodules can reduce the need for surgery Dupuytren disease should be included in the differential diagnosis of a nodule in the palm or fingers or contracture of the fingers of children. Imaging studies can be misleading as in this case in which magnetic resonance imaging suggested both lesions to be fibrous histiocytoma

Dupuytren contracture is a benign, myeloproliferative progressive disease of the palmar fascia which results in shortening, thickening, and fibrosis of the fascia and aponeurosis of the palm The differential diagnosis includes Dupuytren contracture, which is a flexion contracture most commonly involving digits 4 and/or 5 Dupuytren's contracture is characterized by two underlying lesions, nodules and cords. These involve the palmar fascia at the distal palmar crease, especially at the level of the third and fourth rays with progressive disabling finger contracture A tender nodule or mass may be palpable at the level of the metacarpal head in the palm. The finger can be fully extended with a notable click. It is most commonly seen in women aged over 40 years. Ulnar nerve palsy (for example, claw hand) What is the differential diagnosis for Dupuytren contracture? Dupuytren contracture should be distinguished from the following conditions: Palmar fibromatosis (fasciitis) — this is characterised by flexion contractures affecting all the fingers; palmar fibromatosis is associated with malignanc

Histological findings were consistent with Dupuytren's disease and the patient's symptoms improved post excision of the nodule. Although Dupuytren's nodules occur rarely in the wrist, they should be considered as part of the differential diagnosis of wrist lumps and they have the potential to impact on nearby neural structures Dupuytren's disease in children is uncommon; only a few histologically confirmed diagnoses are found in literature. In its early, proliferative phase with many fibroblasts, it can resemble the.

Dupuytren's disease in children—differential diagnosis

  1. Dupuytren's contracture is a relatively common disorder characterized by progressive fibrosis of the palmar fascia [ 1 ]. It is a benign, slowly progressive fibroproliferative disease of the palmar fascia. Initial fascial thickening is usually seen as a nodule in the palm, which can be painful or painless and often goes unnoticed and undiagnosed
  2. Dupuytren's contracture causes skin thickening, tethering, puckering, pitting, or dimpling on the palm, with firm nodules fixed to the skin and deep fascia of the palm or fingers. The nodules can occur anywhere in the palm or fingers, but the most common site is the distal palmar crease, in line with the ring or little finger
  3. Dupuytren's contracture is an abnormal thickening of the skin in the palm of the hand. The skin may develop into a hard lump. Over time it can cause 1 or more fingers to curl (contract) or pull in toward the palm. You may not be able to use your hand for certain things. In many cases, both hands are affected
  4. Ushijima M, Tsuneyoshi M, Enjoji M. Dupuytren type fibromatoses. A clinicopathologic study of 62 cases. Acta Pathol Jpn 1984 Sep;34(5):991-1001; Iwasaki H, Muller H, Stutte HJ, Brennscheidt U. Palmar fibromatosis (Dupuytren's contracture). Ultrastructural and enzyme histochemical studies of 43 cases
  5. Dupuytren's contracture is an inherited disease that results in progressive fibrous tissue contracture of the palmar fascia

Trigger finger and Dupuytren's contracture are both problems that affect the fingers and so one issue is often confused for the other. On the palmar side of each finger, there is a tendon that helps each finger bend toward the palm. Each of these tendons is surrounded by a sheath which is lined with synovium. Synovium produces a fluid that allows the tendon to glide easily a Dupuytren's disease: diagnosis and treatment. Am Fam Physician. 2007 Jul 1. 76(1):86-9. Strickland JW, Leibovic SJ. Anatomy and pathogenesis of the digital cords and nodules. Hand Clin. 1991 Nov. 7(4):645-57; discussion 659-60. Gosset J. Dupuytren's disease and the anatomy of the palmodigital aponeurosis. Hueston JT, Tubiana R. Dupuytren. differential diagnosis may arise unless this distinct clinical entity is well known. In this paper, the term disease is used instead of contracture because, in the foot, con-tractures are rare since extension of the fascia to the phalanges is either absent or insignificant. CHARACTERISTICS In the foot, the lesion is characterized by nodule for Dupuytren's Disease (or simply Dupuytren's) is a progressive disorder characterized by fibrosis of the palmar fascia. Dupuytren's is associated with the formation of palpable nodules and cords in the palm and fingers. In its later stages Dupuytren's causes fixed digital flexion contractures

Dupuytren's Disease: Diagnosis and Treatmen

  1. Diagnosis. Initially, DD of the hand presents with painless localized palm skin thickening, pitting, or palmar nodules . The differential diagnoses include stenosing tenosynovitis, skin callus, or soft-tissue tumor. The ring finger is most often affected, followed by the small finger, middle finger, index finger, and thumb
  2. al desmoid.
  3. Dupuytren's contracture is a condition that causes nodules, or knots, to form underneath the skin of your fingers and palms. It can cause your fingers to become stuck in place. It most commonly.
Management of Dupuytren’s disease | Plastic Surgery Key

Dupuytren's contracture Radiology Reference Article

Although fibroma of tendon sheath is typically sclerotic and nodular fasciitis is typically not, there is sufficient variation in patterns to cause overlap A Dupuytren's contracture is a common condition* involving contraction of the longitudinal palmar fascia.. Typically starting as painless nodules, fibrous cords and flexion contractures develop at the MCP and interphalangeal joints, which can severely limiting digital movement and reduce patient quality of life. The condition is around six times more common in men, with peak onset aged 40-60yrs What is the differential diagnosis for Dupuytren's disease (including isolated nodules)? 1. Ganglion 2. Inclusion cyst 3. Epithelioid sarcoma 4. Camptodactyly 5. Trigger finger 6. Boutonniere's deformity. How does one differentiate a Boutonniere's deformity from a severe PIP joint flexion contracture Dupuytren's disease is a condition that affects the fascia—the fibrous layer of tissue that lies underneath the skin in the palm and fingers. In patients with Dupuytren's, the fascia thickens, then tightens over time. This causes the fingers to be pulled inward, towards the palm, resulting in what is known as a Dupuytren's contracture Dupuytren's disease in infants is exceedingly rare, and diagnosis of Dupuytren's disease is usually confirmed by histology. This case is being reported to show the plethora of possibilities that can form the differential diagnosis of nodules and fibrotic bands in infant's hand, and in all this Dupuytren's disease, though rare, should not be.

Corticosteroid Injection in the Management of Dupuytren

Diagnosis of Dupuytren's The British Dupuytren's Societ

  1. Long answer. The most likely diagnosis is Dupuytren's disease.1 This is a fibroproliferative disease of the palmar fascia, which can lead to permanent flexion contractures of affected digits. Dupuytren's disease mainly affects older men of northern European descent. Prevalence ranges from 0.6% to 31.6% in general populations in Western countries and increases with age.2 The disease has a.
  2. Alerts and Notices Synopsis Causes / typical injury mechanism: Dupuytren disease is a fibroproliferative condition involving the palmar aponeurosis. Classic history and presentation: Initial symptoms include thickened nodules or plaques (grade 1), which are followed by fibrous band development (grade 2). With progression and increased fibrosis, flexion contractures develop as bands cross the.
  3. Dupuytren's contracture. Dupuytren's contracture is a painless deformity of the hand in which one or more fingers (in this case, the two fingers farthest from the thumb) are bent toward the palm and can't be fully straightened. It results from a thickening and scarring of connective tissue under the skin in the palm of the hand and in the fingers
  4. Suspect Dupuytren's disease if a person develops signs and symptoms, including: Skin thickening, tethering, puckering, pitting, or dimpling on the palm. Firm nodules fixed to the skin and deep fascia of the palm or fingers. Nodules can occur anywhere in the palm or fingers. The most common site is the distal palmar crease, in line with the.

It is, however, good to realize that nodules and cords may occur simultaneously and that nodules may even be found within cords, and that therefore the prognostic value of histological analysis of Dupuytren tissue remains controversial today, as compared to clinical parameters for fibrosis diathesis. Clinical Assessment and Differential Diagnosis A lung (pulmonary) nodule is an abnormal growth that forms in a lung. You may have one nodule on the lung or several nodules. Nodules may develop in one lung or both. Most lung nodules are benign (not cancerous). Rarely, pulmonary nodules are a sign of lung cancer. Lung nodules show up on imaging scans like X-rays or CT scans The clinical presentation of Dupuytren's disease is discussed with emphasis on dermato-pathology, the nodule, the cord, ectopic manifestations regional and distant, and disease progression. The differential diagnosis also is described with a list of pseudo-Dupuytren's disease cases Reilly RM1, Stern PJ, Goldfarb CA. A retrospective review of the management of Dupuytren's nodules. J Hand Surg Am 2005;30:1014-18. Mikkelsen OA. Knuckle pads in Dupuytren's disease. Hand 1977;9:301-05. Gossrau G, Selle W. On the coincidence of induration penis plastica, Dupuytren's contracture and knuckle pads An important differential diagnosis to consider here is fibrosarcoma, which has a histological similarity to Dupuytren's nodules and may have a higher incidence in patients with Dupuytren's contracture.3. Ectopic Dupuytren's disease in the wrist is extremely rare with few reports in the literature

Dupuytren's contracture of the right little finger. Arrow marks the area of scarring. Initially, painless nodules are present longitudinally along the lines of tension. Contracture deformities within fascial bands of the hand occur when the nodules form cords. Blanching of the digit on extension. Proximal to the nodules, the cords are painless Diagnosis of Dupuytren's disease typically involves feeling the palm areas to check for nodules and recording how many nodules are found. Your doctor will likely ask you to try to place your hands. This is why an experienced hand physician is needed to make a differential diagnosis. As it progresses the nodules change state, soft to firm and cords will develop from the nodules. At this stage you may notice cords and no nodules, the nodules have progressed, or there may be other developing nodules Clinical manifestation. Asymptomatic, palmar skin nodule, generally within the distal aspect of the palm, often with puckering of the skin above the nodularity; overlying skin sometimes adherent to the fascia, and fibrous cord sometimes extending into the finger; ring finger most commonly involved site, followed by the small finger Seven stages of Dupuytren contracture have been described, based on the presence of nodules and the severity of the contracture. Stage 0: no contracture. Stage N: no contracture, palpable nodule. Stage N/1: 0° to 5° contracture, palpable nodule. Stage 1: 6° to 45° contracture. Stage 2: 46° to 90° contracture

Dupuytren's Disease - Radsourc

Dupuytren's contracture happens when the tissue under the skin near your fingers becomes thicker and less flexible. The exact cause is unknown, but it's been linked to: having a family history of the condition. smoking. drinking lots of alcohol. having diabetes or epilepsy Back to pathway Dupuytren's contracture - clinical presentation · skin thickening or pitting on the palm · firm nodules that are fixed to the skin and deep fascia of the palm or fingers: · commonly near the distal crease of the palm, in line with the ring or little finger · can occur anywhere in the palm or fingers · nodules can be painful in the early stages due to local inflammation. Dupuytren's disease: diagnosis and treatment. Am Fam Physician. 2007; 76(1):86-9 (ISSN: 0002-838X) Trojian TH; Chu SM. Dupuytren's disease is a progressive condition that causes the fibrous tissue of the palmar fascia to shorten and thicken Ledderhose disease, also called Ledderhose's Disease (LD), plantar fibromas, or Morbus Ledderhose is a fibromatosis, like Dupuytren's contracture. When suffering from Ledderhose disease benign nodules grow at the arch of the foot. Initially these nodules are usually painless but as they grow they can cause considerable pain when walking Dupuytren's contracture is the curling of the fingers that occurs as a result of Dupuytren's disease, a problem with unregulated collagen formation in the palm of the hand and fingers. The excess collagen formation causes firm collections, called nodules, and string-like collections called cords

Management of Dupuytren's disease Plastic Surgery Ke

common. Dupuytren contracture is predominantly seen in men of northern European descent aged >40 years. common. difficulties with manual activities. common. Patients describe difficulties with face washing, combing their hair, and putting their hands in their pockets or fitting them into gloves. common. palmar nodule Nodules will grow slowly but will stop growing eventually and stay one size. including Dupuytren's or Peyronie disease. and self-diagnosis can put a person at risk of improper treatment Dupuytren's disease in children can resemble tumours and may have a similar, infiltrative, histological appearance 'with bands of proliferative spindle cells that blend with the surrounding tissue'.7 Tumours that need to be considered in the differential diagnosis include extra-abdominal fibromatosis,3 calcifying aponeurotic fibroma,7,9.

Differential Diagnosis. There are a number of possible causes of hoarseness, including benign laryngeal conditions, infective, neurological, malignant, and functional. Functional causes should be seen as a diagnosis of exclusion when no cause can be found, however it is a common cause for hoarseness. By Drtbalu / Public domain Dupuytrens contracture presentation. 1. Dupuytren's Contracture. 2. Patient Complaints Fingers get in the way with: Washing face Combing hair Putting hand in pocket Racquet sports Golf Putting hand in glove. 3. Symptoms First notice tender nodule or progressive palmar cord development. Painless, and may avoid care until joint motion reduced

Pathology Outlines - Fibromatosis-palmar / planta

Differential diagnosis of a mass on the sole of the foot includes plantar fasciitis (the most frequent lesion of a swelling of the plantar fascia), leiomyoma, rhabdomyosarcoma, neurofibroma, and liposarcoma. Correlation of clinical, radiological, and histological findings helps in confirming a diagnosis Dupuytren disease (DD) is the most common heritable disorder affecting connective tissues. It is an inherited, benign, chronic progressive condition that results in fibrotic changes of the palmar and digital fascia and adjacent soft tissues. DD causes tissues to shorten along lines of mechanical tension, limiting digit extension. Dupuytren contracture (DC) is the end resul A 28-year-old woman with an unremarkable medical history presented with an enlarging nodule that had been growing under her left great toenail for 6 months. The patient monitored the nodule, hoping that it would resolve on its own, but found that it steadily increased in size and began to displace the nail, causing pain Dupuytren's contracture is usually diagnosed clinically. Magnetic resonance imaging or ultrasound may be useful for the differential diagnosis including tenosynovitis, trigger finger, ganglion cyst, soft tissue mass or for imaging of vascular complications. Main findings are fibrous nodules and cord-like thickening in palmar fascia. The. that help in the differential diagnosis and planning of a surgery. ULTRASONOGRAPHY Ultrasound is a useful imaging technique for differential diagnosis of pathologies involving the palmar surface of the hand, demonstrating the thickness of the palmar fascia as well the presence of a nodule (3) (Fig 6). This disease is characterized by hypoechoi

Dupuytren's contracture (also called Dupuytren's disease) is an abnormal thickening of the skin of the palm of the hand at the base of the fingers. Knots of tissue form under the skin, creating a thick cord that can cause one or more fingers to curl in toward the palm or pull sideways in a bent position, typically the ring finger and little. Dupuytren's disease is a common condition that many people have probably never heard of. The disease causes knots of tissue to form under the skin of the hand, slowly pulling one or more fingers into a bent position. The fingers then cannot be straightened back out, leaving the hand deformed Dupuytren's disease (DD) is a fibroproliferative disorder of the palmar and digital fascia, whereby a thick collagen cord develops, causing flexion deformity of the affected metacarpophalangeal (MP) or proximal interphalangeal (PIP) joints. Dupuytren's has a strong genetic link, and patients with Type II diabetes mellitus are more likely to. Differential Diagnosis - The 3 P's surfaced pink nodule . Fibroma - Clinical Features •F>M, 4th-6th decade •Commonly located along the bite line of the buccal mucosa •Sessile, smooth-surfaced pink nodule . Fibroma - Clinical Feature

What is the difference between a Dupuytren's nodule and

Thyroid Nodule Differential Diagnosis. Neck masses can be mistaken with thyroid nodules. While the diagnosis of a thyroid nodule is established, thyroid nodule should be differentiated based on benign or malignant features and the type of nodule: Disease Manifestation Spread Nodular growth Laboratory Imaging Patholog May be associated with carcinoid syndrome, Dupuytren contracture. May be associated with beta blockers, thiazides ( J Sex Med 2010;7:1529 ), hypertension, diabetes and immune reactions. Fibrosis produces an abnormal curvature of the penis, which may cause pain during erection and intercourse. In some cases, nodules adherent to tunica albuginea.

Dupuytren Contracture: Practice Essentials, Anatomy

Dupuytrens Contracture. Nonsurgical Treatment for Dupuytren's Contracture include: Stretching Stretching is usually recommended for the mildest forms of Dupuytren's. Steroid Injections Strong anti-inflammatory drugs are recommended to be injected into a Dupuytren's nodule to bring down the size of nodules in the beginning course of the. • Examine the pathologic differential diagnosis of ground glass nodules and other mass lesions worrisome for malignancy • Recognize features that discriminate between reactive and neoplastic alveolar proliferations • Define the features of in situ and invasive adenocarcinomas of the lung • Examine diagnostic reproducibilit

Dupuytren and nerve problems? Dupuytren Research Grou

Dupuytren's Contracture is a genetic disease that affects the hands and fingers. The condition causes the fascia, a layer of tissue underneath the palm of the hand, to thicken. This can cause the fingers of one or both hands to contract toward the palm, making it difficult for even daily activities Dupuytren's (pronounced DOO-pa-trens) is a hand condition that leads to thickening of tissue in the palm, known as the palmar fascia. This fascia becomes thickened over time, and nodules and. Diagnosis confirmation. Differential diagnosis includes: - granuloma annulare (annular brown-red dermal plaques with minimal to no surface change, typically starts as a papule) - erythema elevatum diutinum (papules and nodules of the extensor surfaces, slightly tender) - foreign body reaction (solitary inflammed tender papule/nodule Knuckle pads appear as slowly growing cutaneous thickenings over the dorsal aspects of the digital joints [1].They may be idiopathic or related to repetitive friction or pressure [2, 3] like in our case report.Knuckle pads occur in association with several fibrosing diseases (Dupuytren's contracture, Ledderhosés syndrome and Peyronie's disease) and are part of the autosomal dominant Bart. Comparisons may be useful for a differential diagnosis: Cytophagic histiocytic panniculitis is a rare disorder affecting the skin and the layers of fatty (adipose) tissue directly under the skin (subcutaneous). The first symptom of this disease is typically the appearance of reddened and tender nodules (lesions) under the skin

The diagnosis of Ledderhose disease is usuallyclinical and does not frequently require confirmation.12 However, Omor et al reported that magnetic resonance imaging has an important role in diagnosis and evaluating the severity of disease.10 The differential diagnosis of plantar masses in-cludes plantar fasciitis, leiomyoma, rhabdomyosarcoma, an Dupuytren's cannot be cured. The symptoms can be treated. If someone is unable to lay the hand flat on a table due to the contracture or bend, this can be treated. How is Dupuytren's Contracture Treated? Early on, the nodule can be massaged. Massaging the nodules with something like a golf ball or a similar device may help The differential diagnosis of intracranial cystic lesions at head ultrasonography (US) includes a broad spectrum of conditions: (a) normal variants, (b) developmental cystic lesions, (c) cysts due to perinatal injury, (d) vascular cystlike structures, (e) hemorrhagic cysts, and (f) infectious cysts. These lesions vary in prevalence from common (cavum of the septum pellucidum, subependymal cyst. Dupuytren's contracture, also known as Dupuytren's disease, is a hand deformity that causes the tissue beneath the surface of the hand to thicken and contract

The differential diagnosis includes BCA, PCLD, hydatid cysts, cystic metastases from primary cystic tumors, and cystic necrosis of large solid neoplasms. Cysts that have internal septations, fenestrations, calcifications, irregular walls, or daughter cysts on US should be evaluated with CT or MRI for features of BCA or hydatid cysts The index finger and thumb usually are spared. The differential diagnosis includes stenosing tenosynovitis, trigger finger, a ganglion cyst, and a soft tissue mass (eg, sarcoma). Treatment Treatment for patients with Dupuytren contracture may be conservative or surgical. Nonoperative options include corticosteroid injection and injection of. The definition of a classical solitary pulmonary nodule is a single, spherical, well-circumscribed, radiographic opacity less than or equal to 30 mm in diameter that is completely surrounded by aerated lung and is not associated with atelectasis, hilar enlargement, or pleural effusion (1, 11).The differential diagnosis includes malignancies, such as bronchogenic carcinoma, carcinoid tumors.


The craniocaudal distribution of nodules is helpful in the differential diagnosis of nodular lung disease . Certain diseases, such as sarcoidosis and other granulomatous diseases, tend to predominate in the upper lobes ( Fig. 3.1A-C ), whereas others, such as hematogenous metastases, tend to be lower lobe predominant ( Fig. 3.2A, B ) Differential Diagnosis of Miliary Pattern of Micronodules Miliary nodules are a subset of randomly distributednodules. Althoughthe term miliary is used widely for the description of diffuse pulmonary micronodules, it should be confined to randomly distributed micronodules. The miliary pattern is common to variou Dupuytren's subungual exostosis (SE) is a rare heterotopic The diagnosis is confirmed by radiography or histology. Differential diagnosis includes viral warts, pyogenic granuloma and osteochondroma. Papillomavirus periungual friable nodule with erosive surface and tendency to bleed unde Dupuytren's disease. 1. Dr Akasha Amber, Pgr Plastic & Reconstructive Surgery Unit,BVH,BWP. 2. History • Baron Guillaume Dupuytren Described it in a lecture in 1831 • Felix Plater 1st described it in 1614 • Henry Cline described pathological anatomy and features of this disease. 3

Dupuytren in a Child: Rare Presentation of a Rare Clinical

䉬 1571 1572 DCP VERSUS DDN IN DUPUYTREN'S DISEASE subcutaneous tumor-like growths that are akin to the DD versus non-DD palmar Dupuytren nodules. However, he occasionally Non-DD is a common clinical entity that can be called these lesions nodules, but more often referred to confused with DD Dupuytren's contracture occurs when the connective tissue in the palm thickens. Often the tissue thickens in one small area first and a nodule forms (a small, hard lump about 0.5-1cm) under the skin of the palm

Dupuytren Subungual Exostosis

Dupuytren's Contracture - Physiopedi

Making a Differential Diagnosis Ester Pereiraa, d, Paula Estanqueirob, Oscar Tellecheac, Manuel Salgadob Abstract Knuckle pads, circumscribed thickening of the skin over the finger joints, most often occur in teenagers and young adults and should be included in the vast differential diagnosis of cutaneous lesions of the hands and feet Symptoms of Dupuytren's contracture usually include lumps, nodules, and bands or cords on the palmar side of the hands. The lumps are generally firm and stuck to the skin of the palm. Skin can seem thicker and puckered. Think of the Dupuytren's palm skin like a road. Some areas are swollen and puffy like a speed bump

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Abstract Dupuytren disease is a nonmalignant, slowly progressive fibroproliferative disorder causing progressive thickening and shortening of the palmar fascia leading to debilitating digital and permanent contracture. Dupuytren contracture belongs to the group of fibromatoses. A wide range of procedural, rehabilitation, and surgical options exists Some also attempt to distinguish 'Dupuytren nodules ' and ' dorsal cutaneous pads', the former occurring only in patients with Dupuytren contracture and the latter occurring in both control and Dupuytren contracture populations. Knuckle pads most commonly become apparent after the age of 30 years Histologically, these nodules were mostly cellular. Three of the nodules had a low signal intensity on both T1- and T2-weighted images and were hypocellular histologically. We conclude that MR imaging can be used to define palmar involvement in Dupuytren's contracture Prurigo nodularis is a chronic condition of uncertain etiology. Although exact prevalence is unknown, it is most commonly seen in patients aged 45 years and older and seems to be more common in women and in people of color. Patients present with one or more (usually multiple) discrete, severely pruritic nodules that mostly appear on the.